Karev is far from the first main cast member to depart the long-running medical soap over the years, fans have gotten used to saying hard farewells to beloved characters like Derek, Cristina, George, Izzie, Callie, Arizona, April, and many more. It turns out that the last time viewers saw Alex was the last time viewers will ever see Alex, even if they didn't know it, as Justin Chambers announced during the show's winter hiatus that he (and therefore Alex) was leaving Grey's, and that his final episode had already aired on Nov. He has been a rock for the show, one of only four original cast members left a decade and a half into the series' run, and one of only two of the original crop of interns left, along with Meredith - which just makes it that much harder to say goodbye. For 16 years, Justin Chambers has been a constant in the lives of many TV watchers, providing countless hilarious, moving, memorable moments as Alex Karev on Grey's Anatomy.
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